Gamitrinib TPP
Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
Product Specifications
CAS Number
[1131626-46-4]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Gamitrinib_TPP.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)C(NCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=C(C[C@H](C[C@@H]2OC)C)C1=O
Molecular Formula
C52H65N3O8P
Molecular Weight
891.06
References & Citations
[1]Markus D. Siegelin, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr 1; 121 (4) : 1349–1360.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Citation 01
Cancer Lett. 2025 Aug 9:632:217977.|Exp Ther Med. 2021 Nov;22 (5) :1246.|bioRxiv. 2024 Jan 2.|bioRxiv. 2024 September 03.|Cancer Lett. 2022 Nov 28:549:215915.|Clin Cancer Res. 2022 May 13;28 (10) :2180-2195.|Elife. 2021 Jun 16:10:e63104.|Front Biosci (Landmark Ed) . 2023 Sep 26;28 (9) :227.|J Invest Dermatol. 2025 Feb 18:S0022-202X (25) 00110-1.|Nature. 2020 Mar;579 (7799) :433-437. |Research Square Preprint. 2020 Sep.|Sci Adv. 2025 Oct 24;11 (43) :eadw6064.|SSRN. 2023 Jul 11.
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