Sepantronium (hydrochloride)
Product Specifications
UNSPSC Description
Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity[1].
Target Antigen
Autophagy; Survivin
Type
Reference compound
Related Pathways
Apoptosis;Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ym-155-hydrochloride.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2[N+](CC3=NC=CN=C3)=C(C)N1CCOC)C4=C(C=CC=C4)C2=O.[Cl-]
Molecular Weight
398.84
References & Citations
[1]Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21.|[2]Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.|[3]Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6(25):21137-47.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10194A/Sepantronium-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10194A/
Clinical Information
Phase 2
CAS Number
355406-09-6
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![[IHC]Cytokeratin 5/6 Mouse Monoclonal Antibody, 1 pack = 100 µL](https://cdn.genprice.uk/genprice/genprice5.png)
H-006-10 100 mL
Secreted Frizzled-Related Protein 2 (SFRP 2) (25-50) (Human) - Antibody
Ask
View Details