LYN-1604 (hydrochloride)

LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[2216753-86-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LYN-1604_hydrochloride.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1.[H]Cl

Molecular Formula

C33H44Cl3N3O2

Molecular Weight

621.08

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8 (4) :2687-2701.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ULK1

Citation 01

Biochem J. 2019 Mar 12;476 (5) :875-887.|Antioxidants (Basel) . 2025 Nov 19;14 (11) :1381.|Cell Signal. 2024 Jun:118:111136.|J Transl Med. 2025 Oct 21;23 (1) :1144.|Oxid Med Cell Longev. 2021 Nov 15:2021:2896674.