LYN-1604
LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC) [1].
Product Specifications
CAS Number
2088939-99-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LYN-1604.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1
Molecular Formula
C33H43Cl2N3O2
Molecular Weight
584.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8 (4) :2687-2701.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1
Citation 01
Antioxidants (Basel) . 2025 Nov 19;14 (11) :1381.|Cell Signal. 2024 Jun:118:111136.|J Transl Med. 2025 Oct 21;23 (1) :1144.|Biochem J. 2019 Mar 12;476 (5) :875-887.|Oxid Med Cell Longev. 2021 Nov 15:2021:2896674.
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