TG 100572
TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
Product Specifications
CAS Number
867334-05-2
UNSPSC
12352005
Target
FGFR; PDGFR; Src; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TG-100572.html
Solubility
DMSO : ≥ 150 mg/mL
Smiles
ClC1=CC=C(O)C=C1C2=CC(C)=C(N=C(NC(C=C3)=CC=C3OCCN4CCCC4)N=N5)C5=C2
Molecular Formula
C26H26ClN5O2
Molecular Weight
475.97
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1
Citation 01
ACS Appl Mater Interfaces. 2025 Aug 6;17 (31) :44160-44177.|Am J Pathol. 2019 Oct;189 (10) :2090-2101.|Science. 2017 Dec 1;358 (6367) :eaan4368.
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Macrophage Expressed Protein 1 (MPG1) Recombinant, Rat