Human BRAF Protein

<strong>Human BRAF Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011648_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 250 µg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> Serine/threonine-protein kinase B-raf protein, B-RAF1 protein, BRAF1 protein, NS7 protein, RAFB1 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Loo E, Khalili P, Beuhler K, Siddiqi I, Vasef MA. BRAF V600E Mutation Across Multiple Tumor Types: Correlation Between DNA-based Sequencing and Mutation-specific Immunohistochemistry Appl Immunohistochem Mol Morphol. 2018 Nov/Dec;26(10):709-713._x000D_ 2: Pakneshan S, Salajegheh A, Smith RA, Lam AK. Clinicopathological relevance of BRAF mutations in human cancer Pathology. 2013 Jun;45(4):346-56._x000D_ 3: Michaloglou C, Vredeveld LC, Mooi WJ, Peeper DS. BRAF(E600) in benign and malignant human tumours Oncogene. 2008 Feb 7;27(7):877-95._x000D_ 4: Discussion Surgery. 2020 Jan;167(1):62-63._x000D_ 5: Cope N, Candelora C, Wong K, Kumar S, Nan H, Grasso M, Novak B, Li Y, Marmorstein R, Wang Z. Mechanism of BRAF Activation through Biochemical Characterization of the Recombinant Full-Length Protein Chembiochem. 2018 Sep 17;19(18):1988-1997._x000D_ 6: Aramini JM, Vorobiev SM, Tuberty LM, Janjua H, Campbell ET, Seetharaman J, Su M, Huang YJ, Acton TB, Xiao R, Tong L, Montelione GT. The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS Structure. 2015 Aug 4;23(8):1382-1393._x000D_ 7: Haling JR, Sudhamsu J, Yen I, Sideris S, Sandoval W, Phung W, Bravo BJ, Giannetti AM, Peck A, Masselot A, Morales T, Smith D, Brandhuber BJ, Hymowitz SG, Malek S. Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling Cancer Cell. 2014 Sep 8;26(3):402-413._x000D_ 8: Chiarion Sileni V. Le decisioni terapeutiche nel melanoma metastatico BRAF mutato Recenti Prog Med. 2021 Apr;112(4):37e-39e._x000D_ 9: Pratilas CA, Solit DB. Therapeutic strategies for targeting BRAF in human cancer Rev Recent Clin Trials. 2007 May;2(2):121-34._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/26898828">10: Hernandez MA, Patel B, Hey F, Giblett S, Davis H, Pritchard C. Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor Cell Signal. 2016 Jun;28(6):561-71. </a>_x000D_ _x000D_ <strong>Products Related to Human BRAF Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>