ZM223
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active[1].
Product Specifications
CAS Number
2031177-48-5
UNSPSC
12352005
Target
NEDD8-activating Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ZM223.html
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2
Molecular Formula
C23H17F3N4O2S2
Molecular Weight
502.53
References & Citations
[1]Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
YP-W18098-01 48 Tests
Human CKLF-like MARVEL transmembrane domain containing 4 (CMTM4) ELISA Kit
Sign In for Pricing
View Details YP-W18098-02 96 Tests
Human CKLF-like MARVEL transmembrane domain containing 4 (CMTM4) ELISA Kit
Sign In for Pricing
View Details 
MBS1174920-01 0.02 mg (E-Coli)
Recombinant Salmonella paratyphi C Protein nrdI (nrdI)
Sign In for Pricing
View Details MBS1174920-02 0.1 mg (E-Coli)
Recombinant Salmonella paratyphi C Protein nrdI (nrdI)
Sign In for Pricing
View Details MBS1174920-03 0.02 mg (Yeast)
Recombinant Salmonella paratyphi C Protein nrdI (nrdI)
Sign In for Pricing
View Details