Alniditan

Alniditan (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan has migraine-preventive effects[1][2].

Product Specifications

CAS Number

[152317-89-0]

Product Name Alternative

Alnitidan

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Alniditan.html

Solubility

10 mM in DMSO

Smiles

C1(NCCCNC[C@H]2CCC3=CC=CC=C3O2)=NCCCN1

Molecular Formula

C17H26N4O

Molecular Weight

302.41

References & Citations

[1]Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382 (2) :103-9.|[2]Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123 (8) :1655-65.