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MHP 133

MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

Product Specifications

CAS Number

[147340-43-0]

UNSPSC

12352005

Target

5-HT Receptor; Cholinesterase (ChE) ; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/MHP_133.html

Solubility

10 mM in DMSO

Smiles

O=C(N/N=C/C1=C(OC(N(C)C)=O)C=CC=[N+]1C)NC2=CC=CC=C2.[Cl-]

Molecular Formula

C17H20ClN5O3

Molecular Weight

377.83

References & Citations

[1]Buccafusco JJ, et al. MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochem Res. 2007 Jul;32 (7) :1224-37. Epub 2007 Apr 3.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; Apolipoprotein D; mAChR1; mAChR2

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