VEGFR-2-IN-9

VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.

Product Specifications

CAS Number

[408502-06-7]

Product Name Alternative

KDR-in-4

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3-[5-[2-[_2-Methoxyethyl_methylamino]ethoxy]-1H-indol-2-yl]-2_1H_-quinolinone.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C=CC=C2)C=C1C(N3)=CC4=C3C=CC(OCCN(CCOC)C)=C4

Molecular Formula

C23H25N3O3

Molecular Weight

391.46

References & Citations

[1]Fang YQ, et al. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step. J Org Chem. 2007 Feb 16;72 (4) :1341-6.|[2]Kinose F, et al. Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor. Molecular Vision 2005; 11:366-373