Abaperidone

Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.

Product Specifications

CAS Number

[183849-43-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Abaperidone.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CO)=COC2=CC(OCCCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=CC=C12

Molecular Formula

C25H25FN2O5

Molecular Weight

452.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bolós J, et al. 7-[3- (1-piperidinyl) propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4- (6-fluoro-1, 2-benzisoxazol-3-yl) -piperidin-1-yl]propoxy]-3- (hydroxymeth yl) chromen -4-one (abaperidone, FI-8602) . J Med Chem. 1998 Dec 31;41 (27) :5402-9.