ABT-639 hydrochloride
ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
Product Specifications
CAS Number
1235560-31-2
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ABT-639_(hydrochloride).html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(C(N2C[C@](CCC3)([H])N3CC2)=O)=C(Cl)C=C1F)(NC4=CC=CC=C4F)=O.Cl
Molecular Formula
C20H21Cl2F2N3O3S
Molecular Weight
492.37
References & Citations
[1]Jarvis MF, et al. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochem Pharmacol. 2014 Jun 15;89 (4) :536-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
T-type calcium channel
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