Lesopitron (dihydrochloride)

Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.

Product Specifications

CAS Number

[132449-89-9]

Product Name Alternative

E4424

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Lesopitron_(dihydrochloride).html

Purity

98.0

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

ClC1=CN(CCCCN2CCN(C3=NC=CC=N3)CC2)N=C1.[H]Cl.[H]Cl

Molecular Formula

C15H23Cl3N6

Molecular Weight

393.74

References & Citations

[1]Haj-Dahmane S, et al. Interactions of Lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. Eur J Pharmacol. 1994 Apr 1;255 (1-3) :185-96.|[2]Ballarín M, et al. Effect of acute administration of the 5-HT1A receptor ligand, Lesopitron, on rat cortical 5-HT and dopamine turnover. Br J Pharmacol. 1994 Oct;113 (2) :425-30.