LY 178002

LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

Product Specifications

CAS Number

[107889-32-7]

UNSPSC

12352005

Target

COX; Lipoxygenase; Phospholipase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/LY_178002.html

Solubility

10 mM in DMSO

Smiles

O=C1NCS/C1=C/C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

Molecular Formula

C18H25NO2S

Molecular Weight

319.46

References & Citations

[1]Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27 (3-4) :300-2.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-LOX; COX; Phospholipase A

Available Sizes

Curated Selection

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