Ralfinamide (mesylate)

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain[1][2].

Product Specifications

CAS Number

[202825-45-4]

Product Name Alternative

FCE-26742A (mesylate)

UNSPSC

12352005

Hazard Statement

H301

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ralfinamide-mesylate.html

Solubility

10 mM in DMSO

Smiles

C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O.CS(=O)(O)=O

Molecular Formula

C18H23FN2O5S

Molecular Weight

398.45

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139 (2) :293-305.|[2]Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34.