L-DABA

L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

Product Specifications

CAS Number

1758-80-1

Product Name Alternative

L-2,4-Diaminobutyric acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/L-DABA.html

Purity

99.89

Solubility

H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](N)CCN

Molecular Formula

C4H10N2O2

Molecular Weight

118.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96 (3) :259-68.|[2]Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5 (3-4) :193-8.|[3]Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21 (2) :143-4.