Dihydrexidine

Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine can stimulate YAP phosphorylation[5].

Product Specifications

CAS Number

123039-93-0

Product Name Alternative

DAR-0100

UNSPSC

12352005

Target

Dopamine Receptor; YAP

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dihydrexidine.html

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1

Molecular Formula

C17H17NO2

Molecular Weight

267.32

References & Citations

[1]Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166 (1) :111-3.|[2]Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262 (1) :383-93.|[3]Salmi P, et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10 (3) :230-42.|[4]Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186 (1), 25–31.|[5]Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150 (4) :780-791.