Desformylflustrabromine hydrochloride

Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.

Product Specifications

CAS Number

[951322-11-5]

Product Name Alternative

Deformylflustrabromine hydrochloride; dFBr hydrochloride

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Desformylflustrabromine_hydrochloride.html

Purity

98.05

Solubility

DMSO : ≥ 105 mg/mL|H2O : 5 mg/mL (ultrasonic)

Smiles

CNCCC1=C(C(C)(C)C=C)NC2=CC(Br)=CC=C12.[H]Cl

Molecular Formula

C16H22BrClN2

Molecular Weight

357.72

References & Citations

[1]Nadezhda German, et al. Deconstruction of the α4β2 Nicotinic Acetylchloine (nACh) Receptor Positive Allosteric Modulator des-Formylflustrabromine (dFBr) . J Med Chem. 2011 Oct 27;54 (20) :7259-67.|[2]Weltzin MM, et al. Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit. J Pharmacol Exp Ther. 2015 Aug;354 (2) :184-94.