APS-2-79 (hydrochloride)

APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].

Product Specifications

CAS Number

[2002381-31-7]

UNSPSC

12352005

Hazard Statement

H302, H361, H372, H410

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/APS-2-79-hydrochloride.html

Purity

98.42

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.Cl

Molecular Formula

C23H22ClN3O3

Molecular Weight

423.89

Precautions

H302, H361, H372, H410

References & Citations

[1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Sep 1;537 (7618) :112-116.