APS-2-79 (hydrochloride)
APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
Product Specifications
CAS Number
[2002381-31-7]
UNSPSC
12352005
Hazard Statement
H302, H361, H372, H410
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/APS-2-79-hydrochloride.html
Purity
98.42
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.Cl
Molecular Formula
C23H22ClN3O3
Molecular Weight
423.89
Precautions
H302, H361, H372, H410
References & Citations
[1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Sep 1;537 (7618) :112-116.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK1
Available Sizes
Curated Selection
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