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BCR-ABL-IN-1

BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.

Product Specifications

CAS Number

188260-50-6

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bcr-Abl

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BCR-ABL-IN-1.html

Solubility

10 mM in DMSO

Smiles

NCCCN1C=CC2=C1C=CC=C2C3=NC(NC4=CC=CC(OC(F)(F)C(F)F)=C4)=NC=C3

Molecular Formula

C23H21F4N5O

Molecular Weight

459.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cui J1, et al. BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives. Bioorg Med Chem Lett. 2013 Apr 15;23 (8) :2442-50.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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