N-type calcium channel blocker-1
N-type calcium channel blocker-1 is an orally active compound which shows high affinity to functionally block N-type calcium channels with an IC50 of 0.7 μM in the IMR32 assay.
Product Specifications
CAS Number
241499-17-2
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/N-type_calcium_channel_blocker-1.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\CN(C1=CC=C(CCC(C)(C)C)C=C1)C2CCN(CC3=CC=C(N(C)C)C=C3)CC2
Molecular Formula
C31H47N3
Molecular Weight
461.73
References & Citations
[1]Hu LY, et al. The discovery of [1- (4-dimethylamino-benzyl) -piperidin-4-yl]-[4- (3,3-dimethylbutyl) -phen yl]- (3-methyl-but-2-enyl) -amine, an N-type Ca+2 channel blocker with oral activity for analgesia. Bioorg Med Chem. 2000 Jun;8 (6) :1203-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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