Uridine 5'-monophosphate

Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3].

Product Specifications

CAS Number

[58-97-9]

Product Name Alternative

5'-Uridylic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Cholinesterase (ChE) ; Endogenous Metabolite; Potassium Channel

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Uridine_monophosphate.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 150 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O

Molecular Formula

C9H13N2O9P

Molecular Weight

324.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10 (7) :4081-4089.|[2]Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058 (1-2) :101-8.|[3]Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41 (7) :697-703.