MK-3328

MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging[1][2].

Product Specifications

CAS Number

[1201323-97-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/MK-3328.html

Purity

99.70

Solubility

10 mM in DMSO

Smiles

CN1C=CC2=CC(C3=NC4=CC=C(F)N=C4O3)=CN=C21

Molecular Formula

C14H9FN4O

Molecular Weight

268.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2 (7) :498-502.|[2]Hostetler ED, et al. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nucl Med Biol. 2011 Nov;38 (8) :1193-203.