FK-448 Free base

FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.

Product Specifications

CAS Number

[85858-76-0]

UNSPSC

12352005

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/FK-448_Free_base.html

Solubility

10 mM in DMSO

Smiles

O=C(C1CCCC2=C1C=CC=C2)OC3=CC=C(C(N4CCN(C(C)C)CC4)=O)C=C3

Molecular Formula

C25H30N2O3

Molecular Weight

406.52

References & Citations

[1]Fujii S, et al. New synthetic inhibitors of chymotrypsin. J Biochem. 1984 Feb;95 (2) :319-22.|[2]Fujii S, et al. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985 Aug;37 (8) :545-9.