FK-448 Free base
Product Specifications
UNSPSC Description
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
Target Antigen
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/FK-448_Free_base.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCCC2=C1C=CC=C2)OC3=CC=C(C(N4CCN(C(C)C)CC4)=O)C=C3
Molecular Weight
406.52
References & Citations
[1]Fujii S, et al. New synthetic inhibitors of chymotrypsin. J Biochem. 1984 Feb;95(2):319-22.|[2]Fujii S, et al. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985 Aug;37(8):545-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100193/FK-448-Free-base-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100193/
Clinical Information
No Development Reported
CAS Number
85858-76-0
Curated Selection
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