Mouse IL-4 Recombinant Protein
IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Mouse IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.
Product Specifications
Synonyms
Interleukin-4; IL-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1; Il4; Il-4
Gene Name
IL4
UniProt
P07750
Source
Yeast
Sequence
[object Object]
Applications
Cell Culture
Field of Research
Adaptive Immunity, Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology
Purification
Ion-exchange chromatography.
Bioactivity
In testing.
Form
Lyophilized
Function
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412) . It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301) . It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301) . It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241) .
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Subcellular Location
Secreted.
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