Human IL-4 Recombinant Protein
IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Human IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.
Product Specifications
Synonyms
Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra; IL4
Gene Name
IL4
UniProt
P05112
Source
Yeast
Sequence
[object Object]
Applications
Cell Culture
Field of Research
Adaptive Immunity, Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology
Purification
Ion-exchange chromatography.
Bioactivity
In testing.
Form
Lyophilized
Function
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727) . It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity) .
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Subcellular Location
Secreted.
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