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Mepyramine maleate (Standard)

Mepyramine maleate (Standard) is the analytical standard of Mepyramine maleate. This product is intended for research and analytical applications. Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.

Product Specifications

CAS Number

59-33-6

Product Name Alternative

Pyrilamine maleate (Standard)

UNSPSC

12352005

Target

Histamine Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/mepyramine-maleate-standard.html

Smiles

CN(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=C2.O=C(O)/C=C\C(O)=O

Molecular Formula

C21H27N3O5

Molecular Weight

401.46

References & Citations

[1]Hill SJ. Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol Rev. 1990 Mar;42 (1) :45-83.|[2]van der Goot H1, et al. Selective ligands as tools to study histamine receptors. Eur J Med Chem. 2000 Jan;35 (1) :5-20.|[3]Fitzsimons CP, et al. Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein. J Biol Chem. 2004 Aug 13;279 (33) :34431-9.|[4]Mojtahedin A, et al. Effects of mepyramine and famotidine on the physostigmine-induced antinociception in the formalin test in rats. Pak J Biol Sci. 2008 Nov 15;11 (22) :2573-8.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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