Gentiopicroside

Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.

Product Specifications

CAS Number

[20831-76-9]

Product Name Alternative

Gentiopicrin

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450; HCV

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Gentiopicroside.html

Purity

99.83

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

C=C[C@@H]([C@@H]1O[C@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CO)C(C3=CO1)=CCOC3=O

Molecular Formula

C16H20O9

Molecular Weight

356.32

Precautions

H302

References & Citations

[1]Deng Y, et al. In vitro inhibition and induction of human liver cytochrome P450 enzymes by gentiopicroside: potent effect on CYP2A6. Drug Metab Pharmacokinet. 2013;28 (4) :339-44. Epub 2013 Feb 19.|[2]Yang Y, et al. Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol-induced gastric mucosal injury in mice. Phytother Res. 2018 Feb;32 (2) :259-266.|[3]Chen F, et al. Gentiopicroside inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and JNK signaling pathways. Biomed Pharmacother. 2018 Apr;100:142-146.