BeKm-1

BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. BeKm-1 can be used for the research of heart disease[1].

Product Specifications

CAS Number

[524962-01-4]

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bekm-1.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]2CC3=CC=CC=C3)=O)=O)=O)=O)NC4=O)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]6CC(O)=O)=O)NC2=O)C(N[C@@H](CC7=CC=CC=C7)C(N8[C@@H](CCC8)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC9=CC=CC=C9)C(O)=O)=O)NC6=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%10=CC=CC=C%10)C(NCC(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]4CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C174H261N51O52S6

Molecular Weight

4091.65

References & Citations

[1]Milnes JT, et al. Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Lett. 2003;547 (1-3) :20-26.