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HER3 (Phospho-Tyr1197) Colorimetric Cell-Based ELISA Kit

The HER3 (Phospho-Tyr1197) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor HER3 (Phospho-Tyr1197) protein expression profile in cells. The kit can be used for measuring the relative amounts of HER3 (Phospho-Tyr1197) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on HER3 (Phospho-Tyr1197) .

Product Specifications

Synonyms

Receptor tyrosine-protein kinase erbB-3;2.7.10.1; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3

Gene Name

ERBB3

UniProt

P21860

Reactivity

Human, Mouse, Rat

Tissue Specificity

Epithelial tissues and brain.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) .

Molecular Weight

148098 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Receptor tyrosine-protein kinase erbB-3

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Frequently Asked Questions

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