Claudin 7 (Phospho-Tyr210) Colorimetric Cell-Based ELISA Kit
The Claudin 7 (Phospho-Tyr210) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Claudin 7 (Phospho-Tyr210) protein expression profile in cells. The kit can be used for measuring the relative amounts of Claudin 7 (Phospho-Tyr210) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Claudin 7 (Phospho-Tyr210) .
Product Specifications
Synonyms
Claudin-7; CLDN-7; CLDN7; CEPTRL2, CPETRL2
Gene Name
CLDN7
UniProt
O95471
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.
Molecular Weight
22418 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Claudin-7
Subcellular Location
Cell membrane; Multi- pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Co-localizes with EPCAM at the basolateral cell membrane and tight junction.
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