WWOX (Phospho-Tyr33) Colorimetric Cell-Based ELISA Kit
The WWOX (Phospho-Tyr33) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor WWOX (Phospho-Tyr33) protein expression profile in cells. The kit can be used for measuring the relative amounts of WWOX (Phospho-Tyr33) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on WWOX (Phospho-Tyr33) .
Product Specifications
Synonyms
WW domain-containing oxidoreductase;1.1.1.-; Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1; WWOX; FOR, SDR41C1, WOX1
Gene Name
WWOX
UniProt
Q96KM3
Reactivity
Human, Mouse
Tissue Specificity
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity) . May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF) -mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Molecular Weight
46677 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
WW domain-containing oxidoreductase
Subcellular Location
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Partially localizes to the mitochondria (PubMed:14695174) . Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity) . Translocates to the nucleus in response to TGFB1 (PubMed:19366691) . Isoform 5 and isoform 6 may localize in the nucleus.
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