GRB2 (Phospho-Ser159) Colorimetric Cell-Based ELISA Kit
GRB2
Product Specifications
Synonyms
GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100; GAB2; KIAA0571
Gene Name
GAB2
UniProt
Q9UQC2
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Molecular Weight
74458 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
GRB2-associated-binding protein 2
Subcellular Location
Cytoplasm. Cell membrane.
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