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FRS2 (Phospho-Tyr436) Colorimetric Cell-Based ELISA Kit

The FRS2 (Phospho-Tyr436) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FRS2 (Phospho-Tyr436) protein expression profile in cells. The kit can be used for measuring the relative amounts of FRS2 (Phospho-Tyr436) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FRS2 (Phospho-Tyr436) .

Product Specifications

Synonyms

Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1; FRS2

Gene Name

FRS2

UniProt

Q8WU20

Reactivity

Human, Mouse

Tissue Specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Molecular Weight

57029 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Fibroblast growth factor receptor substrate 2

Subcellular Location

Endomembrane system. Cytoplasmic, membrane-bound.

Frequently Asked Questions

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