BL-CAM (Phospho-Tyr807) Colorimetric Cell-Based ELISA Kit
The BL-CAM (Phospho-Tyr807) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BL-CAM (Phospho-Tyr807) protein expression profile in cells. The kit can be used for measuring the relative amounts of BL-CAM (Phospho-Tyr807) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BL-CAM (Phospho-Tyr807) .
Product Specifications
Synonyms
B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; CD22; SIGLEC2
Gene Name
CD22
UniProt
P20273
Reactivity
Human
Tissue Specificity
B-lymphocytes.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Molecular Weight
95348 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
B-cell receptor CD22
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
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