Tau (Phospho-Thr231) Colorimetric Cell-Based ELISA Kit

The Tau (Phospho-Thr231) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Tau (Phospho-Thr231) protein expression profile in cells. The kit can be used for measuring the relative amounts of Tau (Phospho-Thr231) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Tau (Phospho-Thr231) .

Product Specifications

Synonyms

Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL, MTBT1, TAU

Gene Name

MAPT

UniProt

P10636

Reactivity

Human, Mouse, Rat

Tissue Specificity

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Molecular Weight

78928 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC2536

Product MSDS

https://www.bosterbio.com/msds?sku=EKC2536

Other Gene Names

Microtubule-associated protein tau

Subcellular Location

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cytoplasm. Cell projection, dendrite. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.