SBI-0640756
Product Specifications
UNSPSC Description
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
Target Antigen
Autophagy; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Autophagy;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SBI-0640756.html
Purity
99.75
Solubility
DMSO : ≥ 26 mg/mL
Smiles
O=C1C(C(/C=C/C2=CC(F)=CN=C2)=O)=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N1
Molecular Weight
404.82
References & Citations
[1]Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19560/SBI-0640756-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19560/SBI-0640756-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1821280-29-8
Available Sizes
Curated Selection
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