SBI-0640756
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
Product Specifications
CAS Number
[1821280-29-8]
Product Name Alternative
SBI-756
UNSPSC
12352005
Target
Autophagy; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SBI-0640756.html
Purity
99.75
Solubility
DMSO : ≥ 26 mg/mL
Smiles
O=C1C(C(/C=C/C2=CC(F)=CN=C2)=O)=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N1
Molecular Formula
C23H14ClFN2O2
Molecular Weight
404.82
References & Citations
[1]Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75 (24) :5211-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF4
Available Sizes
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