SBI-0640756

SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.

Product Specifications

CAS Number

[1821280-29-8]

Product Name Alternative

SBI-756

UNSPSC

12352005

Target

Autophagy; Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SBI-0640756.html

Purity

99.75

Solubility

DMSO : ≥ 26 mg/mL

Smiles

O=C1C(C(/C=C/C2=CC(F)=CN=C2)=O)=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N1

Molecular Formula

C23H14ClFN2O2

Molecular Weight

404.82

References & Citations

[1]Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75 (24) :5211-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EIF4

Available Sizes

Curated Selection

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