P73 (Phospho-Tyr99) Colorimetric Cell-Based ELISA Kit
The p73 (Phospho-Tyr99) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor p73 (Phospho-Tyr99) protein expression profile in cells. The kit can be used for measuring the relative amounts of p73 (Phospho-Tyr99) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on p73 (Phospho-Tyr99) .
Product Specifications
Synonyms
Tumor protein p73; p53-like transcription factor; p53-related protein; TP73; P73
Gene Name
TP73
UniProt
O15350
Reactivity
Human, Mouse
Tissue Specificity
Expressed in striatal neurons of patients with Huntington disease (at protein level) . Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Molecular Weight
69623 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tumor protein p73
Subcellular Location
Nucleus. Cytoplasm. Accumulates in the nucleus in response to DNA damage.
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