FKHRL1 (Phospho-Ser253) Colorimetric Cell-Based ELISA Kit
The FKHRL1 (Phospho-Ser253) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FKHRL1 (Phospho-Ser253) protein expression profile in cells. The kit can be used for measuring the relative amounts of FKHRL1 (Phospho-Ser253) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FKHRL1 (Phospho-Ser253) .
Product Specifications
Synonyms
Forkhead box protein O3 ; AF6q21 protein ; Forkhead in rhabdomyosarcoma-like 1 ; FOXO3 ; FKHRL1 , FOXO3A
Gene Name
FOXO3 FKHRL1 , FOXO3A
UniProt
O43524
Reactivity
Human, Mouse, Rat
Tissue Specificity
Ubiquitous.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Molecular Weight
71277 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Forkhead box protein O3
Subcellular Location
Cytoplasm, cytosol. Nucleus. Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
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