P56 Dok-2 (Phospho-Tyr299) Colorimetric Cell-Based ELISA Kit

The p56 Dok-2 (Phospho-Tyr299) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor p56 Dok-2 (Phospho-Tyr299) protein expression profile in cells. The kit can be used for measuring the relative amounts of p56 Dok-2 (Phospho-Tyr299) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on p56 Dok-2 (Phospho-Tyr299) .

Product Specifications

Synonyms

Docking protein 2; Downstream of tyrosine kinase 2; p56 (dok-2) ; DOK2

Gene Name

DOK2

UniProt

O60496

Reactivity

Human, Mouse

Tissue Specificity

Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) .