Caveolin-1 (Phospho-Tyr14) Colorimetric Cell-Based ELISA Kit
The Caveolin-1 (Phospho-Tyr14) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caveolin-1 (Phospho-Tyr14) protein expression profile in cells. The kit can be used for measuring the relative amounts of Caveolin-1 (Phospho-Tyr14) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caveolin-1 (Phospho-Tyr14) .
Product Specifications
Synonyms
Caveolin-1; CAV1; CAV
Gene Name
CAV1
UniProt
Q03135
Reactivity
Human, Mouse, Rat
Tissue Specificity
Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level) . Expressed in the brain.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity) . Involved in the costimulatory signal essential for T-cell receptor (TCR) - mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292) . Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564) .
Molecular Weight
20472 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Caveolin-1
Subcellular Location
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae.
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