BCL-2 (Phospho-Ser70) Colorimetric Cell-Based ELISA Kit
The BCL-2 (Phospho-Ser70) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BCL-2 (Phospho-Ser70) protein expression profile in cells. The kit can be used for measuring the relative amounts of BCL-2 (Phospho-Ser70) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BCL-2 (Phospho-Ser70) .
Product Specifications
Synonyms
Apoptosis regulator Bcl-2; BCL2
Gene Name
BCL2
UniProt
P10415
Reactivity
Human
Tissue Specificity
Expressed in a variety of tissues.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .
Molecular Weight
26266 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Apoptosis regulator Bcl-2
Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
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