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Vitamin D Receptor (Phospho-Ser208) Colorimetric Cell-Based ELISA Kit

The Vitamin D Receptor (Phospho-Ser208) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Vitamin D Receptor (Phospho-Ser208) protein expression profile in cells. The kit can be used for measuring the relative amounts of Vitamin D Receptor (Phospho-Ser208) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Vitamin D Receptor (Phospho-Ser208) .

Product Specifications

Synonyms

Vitamin D3 receptor; VDR;1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR; NR1I1

Gene Name

VDR

UniProt

P11473

Reactivity

Human

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

Molecular Weight

48289 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Vitamin D3 receptor

Subcellular Location

Nucleus. Cytoplasm. Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3.

Frequently Asked Questions

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