TERF1 (Phospho-Ser219) Colorimetric Cell-Based ELISA Kit
The TERF1 (Phospho-Ser219) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor TERF1 (Phospho-Ser219) protein expression profile in cells. The kit can be used for measuring the relative amounts of TERF1 (Phospho-Ser219) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on TERF1 (Phospho-Ser219) .
Product Specifications
Synonyms
Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1; TERF1; PIN2, TRBF1, TRF, TRF1
Gene Name
TERF1
UniProt
P54274
Reactivity
Human, Mouse
Tissue Specificity
Highly expressed and ubiquitous. Isoform Pin2 predominates.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Molecular Weight
50246 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Telomeric repeat-binding factor 1
Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
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