What is the catalog number for NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit?

The catalog number for NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit is EKC2323.

What sizes are available for NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit?

NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit is available in the following size(s): 1 Kit, Containing two 96 Well Plates and all necessary reagents.

Where can I find the safety data sheet (SDS/MSDS) for NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit?

The safety data sheet for NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit is available here: https://www.bosterbio.com/msds?sku=EKC2323.

NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit

Q: Is NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit in stock?

NPM (Phospho-Thr234) Colorimetric Cell-Based ELISA Kit is currently made to order / not held in immediate stock. Contact us for lead time.

The NPM (Phospho-Thr234) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor NPM (Phospho-Thr234) protein expression profile in cells. The kit can be used for measuring the relative amounts of NPM (Phospho-Thr234) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on NPM (Phospho-Thr234) .

Product Specifications

Synonyms

B23.1; NPM isoform 1; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin) Numatrin

Gene Name

NPM1

UniProt

P06748

Reactivity

Human, Mouse, Rat

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486) . In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029) .

Molecular Weight

32575 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Nucleophosmin

Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.