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NIPA (Phospho-Ser354) Colorimetric Cell-Based ELISA Kit

The NIPA (Phospho-Ser354) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor NIPA (Phospho-Ser354) protein expression profile in cells. The kit can be used for measuring the relative amounts of NIPA (Phospho-Ser354) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on NIPA (Phospho-Ser354) .

Product Specifications

Synonyms

Nuclear interacting partner of ALK; Nuclear-interacting partner of ALK; ZC3HC1

Gene Name

ZC3HC1

UniProt

Q86WB0

Reactivity

Human, Mouse, Rat

Tissue Specificity

Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Essential component of a SCF-type E3 ligase complex, SCF (NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1) . Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF (NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Molecular Weight

55262 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC2322

Product MSDS

https://www.bosterbio.com/msds?sku=EKC2322

Other Gene Names

Nuclear-interacting partner of ALK

Subcellular Location

Nucleus.

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