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Integrin beta4 (Phospho-Tyr1510) Colorimetric Cell-Based ELISA Kit

The Integrin beta4 (Phospho-Tyr1510) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Integrin beta4 (Phospho-Tyr1510) protein expression profile in cells. The kit can be used for measuring the relative amounts of Integrin beta4 (Phospho-Tyr1510) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Integrin beta4 (Phospho-Tyr1510) .

Product Specifications

Synonyms

CD104 antigen; GP150; ITB4; integrin beta-4; integrin beta-4C

Gene Name

ITGB4

UniProt

P16144

Reactivity

Human, Mouse, Rat

Tissue Specificity

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) .

Molecular Weight

202167 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC2303

Product MSDS

https://www.bosterbio.com/msds?sku=EKC2303

Other Gene Names

Integrin beta-4

Subcellular Location

Cell membrane; Single-pass type I membrane protein.Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Curated Selection

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